General Information

  • ID:  hor000529
  • Uniprot ID:  NA
  • Protein name:  Helicostatin-5
  • Gene name:  NA
  • Organism:  Manduca sexta
  • Family:  Allatostatin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  have no allatostatic activity
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  ARAYDFGL
  • Length:  8
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Inhibit spontaneous contractions of the foregut
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor000529_AF2.pdbhor000529_ESM.pdb

Physical Information

Mass: 103706 Formula: C42H61N11O12
Absent amino acids: CEHIKMNPQSTVW Common amino acids: A
pI: 6.34 Basic residues: 1
Polar residues: 2 Hydrophobic residues: 4
Hydrophobicity: 6.25 Boman Index: -1132
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 73.75
Instability Index: 2892.5 Extinction Coefficient cystines: 1490
Absorbance 280nm: 212.86

Literature

  • PubMed ID:  14706525
  • Title:  Identification of Neuropeptides From Brains of Larval Manduca Sexta and Lacanobia Oleracea Using MALDI-TOF Mass Spectrometry and Post-Source Decay